Salmon Sperm Is the Anti-Aging Hero For Neck Wrinkles (2025)

Most of Valmont’s luxury products are laced with PDRN, including this neck cream. Featuring encapsulated salmon DNA technology, it deeply penetrates the skin for fast-acting results.

An LA Suite Skincare reviewer says: "Love how lifting and firming this cream is. I travel across various climates around the world, and this one works in nearly all conditions. Has a dense look but the feel is very emollient that sinks in quite nicely. It pairs beautifully with the Précieux Votre Visage serum or Lifting V serum. It’s great for summer nights, but you’d need something heavier for a dry winter. It’s perfect for a working professional that needs morning de-puffing!"

Medicube makes testing the waters on PDRN very affordable. This serum is under $20 and doesn’t skimp on potency, featuring exosomes that help deliver salmon DNA to the skin more efficiently. What’s more, the formula stars brightening niacinamide and plumping collagen.

An Amazon reviewer writes: "I’d never heard of exosomes, so I did some research and had to try this! I immediately noticed that my products were soaking into my skin completely, and it really does feel like microneedling. I’m 41, and my skin looks and feels incredible (no makeup or filters)! There is no residue or stickiness. It’s super effective, and the price point is fantastic!

Anua is pretty new to the PDRN topicals game, but it’s already getting some buzz. This serum from the brand stars repairing salmon DNA, a whopping three percent hyaluronic acid, and hydrolyzed collagen to plump and protect the skin.

An Amazon reviewer writes: "My skin has changed almost overnight. I was very happy with my skin care routine before, but I wanted to add in a hyaluronic acid. It began to look so much healthier after only just the first few uses, and better and better every day! I do have sensitive skin, and I tend to have outbreaks when starting new products. I’ve had zero issues incorporating this product into my routine. Highly recommend."

Some labels like MD’s Pick use vegan forms of PDRN to mimic the effects of salmon DNA. "A study with PDRNs derived from ginseng demonstrated skin regeneration and barrier protection capabilities, suggesting that vegan PDRNs are a viable alternative to salmon-derived PDRNs," says Cheung. This formula uses seaweed extract, in particular, to stimulate collagen production. It also contains ultra-fine "bioleedles" coated with hyaluronic acid, which stimulate the skin and allow for deeper product absorption.

An Amazon reviewer says: "I have been applying this in lined areas of my face. The bioneedle technology creates a slightly prickly sensation, but after a few minutes, you don’t notice the feeling anymore. I have noticed a reduction in my smile lines. It is not just a thick product filling in the cracks, it is still noticeable the next day."

Here’s a great balm that’s easy to swipe along the neck and décolleté. Inside the formula is salmon PDRN, salmon collagen, and proteoglycan, another salmon-derived ingredient that helps lock in moisture. Topping off the potent list is Jeju oil, which helps clarify the skin and minimize dullness.

An Amazon reviewer says: "I’ve been using Kahi Wrinkle Bounce for a few weeks now, and I am absolutely thrilled with the results! This product has truly transformed my skin. The texture is luxurious and absorbs quickly, leaving my skin feeling incredibly hydrated and smooth. I’ve noticed a significant reduction in fine lines and wrinkles, and my skin looks more youthful and radiant. The formula is gentle yet effective, making it perfect for daily use. I also love the subtle, pleasant scent."

Also from VT Cosmetics, this wide balm stick doles out a solid amount of product in a single swipe down the neck, delivering Korean wild ginseng extract, a vegan PDRN alternative. (Though keep in mind that experts like Gabby Garritano, a physician’s assistant and founder of JECT, agree salmon-derived PDRN is still the gold standard of PDRN.) Additionally, the product includes collagen to plump and ceramides to further strengthen the skin barrier.

An Amazon reviewer says: "This PDRN stick balm is impressively compact—perfect for on-the-go use. It glides on smoothly, providing a nice dewy finish without feeling greasy."

This gel-like serum combines skin-repairing salmon DNA with equally buzzy snail mucin to lock in moisture and enhance skin barrier function. Also featuring niacinamide, it promises to make the complexion look smoother, brighter, and more supple after just a few uses.

An Amazon reviewer says: "Gangnam’s Glow Mucin serum is a staple in my skin care regimen for my neck! My neck is sensitive, dry, and starting to get crepey with age. I use this serum first before I apply my neck cream, and it makes a huge difference in the appearance of my skin! No more redness, and my skin looks firmer and definitely more hydrated. This has no fragrance and absorbs with a supple finish (not sticky or greasy). Love it!"

Since most PDRN products pair salmon DNA with moisture boosters like hyaluronic acid, you’ll likely notice an immediate dewy effect. Longer-term firming and smoothing effects typically depend on the potency of the PDRN formula you’re using and the state of your skin. "In general, skin improvements, especially the anti-inflammatory benefits, can be seen within weeks," says Cheung.

Garritano adds that, as with any skin service, repetition is the key to long-lasting results. "The most transformative changes are seen after a series of three to four microneedling [sessions] with PDRN treatments spaced four to six weeks apart."

• Jessie Cheung is a board-certified dermatologist and founder of Cheung Aesthetics & Wellness
• Board-certified dermatologist and founder of SOM Aesthetics, Dr. Saami Khalifian
• Gabby Garritano, PA-C is a physician’s assistant and founder of JECT